Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan neck support pillow OEM
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam pillow ODM development service
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution China
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan anti-bacterial pillow ODM design
Scientists have spent decades researching clean and efficient ways to break down plants for use as biofuels and other bioproducts. A species of ants works with a type of fungus to accomplish this naturally. Kristin Burnum-Johnson and her team set out to investigate how this is accomplished at the molecular level. Credit: Illustration by Mike Perkins and Nathan Johnson | Pacific Northwest National Laboratory Scientists at PNNL have devised a novel technique to visualize tiny inner workings of complex fungal community For years, researchers have dedicated themselves to developing methods that can effectively and economically break down plant materials, enabling their transformation into valuable bioproducts that enhance our daily lives. Bio-based fuels, detergents, nutritional supplements, and even plastics are the result of this work. And while scientists have found ways to degrade plants to the extent needed to produce a range of products, certain polymers such as lignin, which is a primary ingredient in the cell wall of plants, remain incredibly difficult to affordably break down without adding pollutants back into the environment. These polymers can be left behind as waste products with no further use. A specialized microbial community composed of fungus, leafcutter ants, and bacteria is known to naturally degrade plants, turning them into nutrients and other components that are absorbed and used by surrounding organisms and systems. But identifying all components and biochemical reactions needed for the process remained a significant challenge—until now. As part of her Department of Energy (DOE) Early Career award, Kristin Burnum-Johnson, science group leader for Functional and Systems Biology at Pacific Northwest National Laboratory (PNNL), and a team of fellow PNNL researchers, developed an imaging method called metabolome informed proteome imaging (MIPI). This method allows scientists to peer deep down to the molecular level and view exactly what base components are part of the plant degradation process, as well as what, when, and where important biochemical reactions occur that make it possible. Using this method, the team revealed important metabolites and enzymes that spur different biochemical reactions that are vital in the degradation process. They also revealed the purpose of resident bacteria in the system—which is to make the process even more efficient. These insights can be applied to future biofuels and bioproducts development. The team’s research was recently published in Nature Chemical Biology. A symbiotic relationship between leafcutter ants and fungi reveal key to success in plant degradation For its research, the team studied a type of fungus known for its symbiotic relationship with a species of leafcutter ants—a fungus known as Leucoagaricus gongylophorus. The ants use the fungus to cultivate a fungal garden that degrades plant polymers and other materials. Remnant components from this degradation process are used and consumed by a variety of organisms in the garden, allowing all to thrive. The ants accomplish this process by cultivating fungus on fresh leaves in specialized underground structures. These structures ultimately become the fungal gardens that consume the material. Resident bacterial members help with the degradation by producing amino acids and vitamins that support the overall garden ecosystem. “Environmental systems have evolved over millions of years to be perfect symbiotic systems,” Burnum-Johnson said. “How can we better learn from these systems than by observing how they accomplish these tasks naturally?” But what makes this fungal community so difficult to study is its complexity. While the plants, fungus, ants, and bacteria are all active components in the plant degradation process, none of them focus on one task or reside in one location. Factor in the small-scale size of the biochemical reactions occurring at the molecular level, and an incredibly difficult puzzle presents itself. But the new MIPI imaging method developed at PNNL allows scientists to see exactly what is going on throughout the degradation process. “We now have the tools to fully understand the intricacies of these systems and visualize them as a whole for the first time,” Burnum-Johnson said. Revealing important components in a complex system Using a high-powered laser, the team took scans across 12-micron-thick sections of a fungal garden—the approximate width of plastic cling film. This process helped determine locations of metabolites in the samples, which are remnant products of plant degradation. This technique also helped identify the location and abundance of plant polymers such as cellulose, xylan, and lignin, as well as other molecules in specific regions. The combined locations of these components indicated hot spots where plant material had been broken down. From there, the team homed in on those regions to see enzymes, which are used to kick-start biochemical reactions in a living system. Knowing the type and location of these enzymes allowed them to determine which microbes were a part of that process. All of these components together helped affirm the fungus as the primary degrader of the plant material in the system. Additionally, the team determined that the bacteria present in the system transformed previously digested plant polymers into metabolites that are used as vitamins and amino acids in the system. These vitamins and amino acids benefit the entire ecosystem by accelerating fungal growth and plant degradation. Burnum-Johnson said if scientists had used other, more traditional methods that take bulk measurements of primary components in a system, such as metabolites, enzymes, and other molecules, they would simply get an average of those materials, creating more noise and masking information. “It dilutes the important chemical reactions of interest, often making these processes undetectable,” she said. “To analyze the complex environmental ecosystems of these fungal communities, we need to know those fine detail interactions. These conclusions can then be taken back into a lab setting and used to create biofuels and bioproducts that are important in our everyday life.” Using knowledge of complex systems for future fungal research Marija Velickovic, a chemist and lead author of the paper, said she initially became interested in studying the fungal garden and how it degrades lignin based on the difficulty of the project. “Fungal gardens are the most interesting because they are one of the most complex ecosystems composed of multiple members that effectively work together,” she said. “I really wanted to map activities at the microscale level to better understand the role of each member in this complex ecosystem.” Velickovic performed all the hands-on experiments in the lab, collecting material for the slides, scanning the samples to view and identify metabolites in each of the sections, and identifying hot spots of lignocellulose degradation. Both Velickovic and Burnum-Johnson said they are ecstatic about their team’s success. “We actually accomplished what we set out for,” Burnum-Johnson said. “Especially in science, that isn’t guaranteed.” The team plans to use its findings for further research, with specific plans to study how fungal communities respond and protect themselves amid disturbances and other perturbations. “We now have an understanding of how these natural systems degrade plant material very well,” Burnum-Johnson said. “By looking at complex environmental systems at this level, we can understand how they are performing that activity and capitalize on it to make biofuels and bioproducts.” Reference: “Mapping microhabitats of lignocellulose decomposition by a microbial consortium” by Marija Veličković, Ruonan Wu, Yuqian Gao, Margaret W. Thairu, Dušan Veličković, Nathalie Munoz, Chaevien S. Clendinen, Aivett Bilbao, Rosalie K. Chu, Priscila M. Lalli, Kevin Zemaitis, Carrie D. Nicora, Jennifer E. Kyle, Daniel Orton, Sarai Williams, Ying Zhu, Rui Zhao, Matthew E. Monroe, Ronald J. Moore, Bobbie-Jo M. Webb-Robertson, Lisa M. Bramer, Cameron R. Currie, Paul D. Piehowski and Kristin E. Burnum-Johnson, 1 February 2024, Nature Chemical Biology. DOI: 10.1038/s41589-023-01536-7 The work was funded by DOE’s Office of Science. Additionally, researchers accessed mass spectrometry imaging and computing and proteomics resources at the Environmental Molecular Sciences Laboratory, an Office of Science user facility located at PNNL.
The decline of Menin in the hypothalamus may contribute to physiological aging, affecting cognition, bone mass, skin thickness, and lifespan. A recent study using mice suggests that a simple dietary supplement of an amino acid may help mitigate some of these age-related changes. Loss of Menin helps drive the aging process, and dietary supplement can reverse it in mice. Cognition, bone mass, skin thickness, and lifespan are all affected by Menin’s decline. According to a new scientific study, the decline in the hypothalamic Menin may play a key role in aging. The findings reveal a previously unknown driver of physiological aging and suggest that supplementation with a simple amino acid may mitigate some age-related changes. The research, by Lige Leng of Xiamen University, Xiamen, China, and colleagues, was published on March 16th in the open access journal PLOS Biology. The hypothalamus has been recognized as a key mediator of physiological aging, through an increase in the process of neuroinflammatory signaling over time. In turn, inflammation promotes multiple age-related processes, both in the brain and the periphery. Researchers find that the loss of a hypothalamic hormone helps drive the aging process, and a supplement can help reverse it in mice. Credit: Lige Leng, Ziqi Yuan and Jie Zhang, 2023, PLOS Biology, CC-BY 4.0 Recently, Leng and colleagues showed that Menin, a hypothalamic protein, is a key inhibitor of hypothalamic neuroinflammation, leading them to ask what role Menin may play in aging. Here, they observed that the level of Menin in the hypothalamus, but not astrocytes or microglia, declines with age. To explore this decline, they created conditional knockout mice, in which Menin activity could be inhibited. They found that reduction of Menin in younger mice led to an increase in hypothalamic neuroinflammation, aging-related phenotypes including reductions in bone mass and skin thickness, cognitive decline, and modestly reduced lifespan. Another change induced by loss of Menin was a decline in levels of the amino acid D-serine, known to be a neurotransmitter and sometimes used as a dietary supplement found in soybeans, eggs, fish, and nuts. The authors showed this decline was due to loss of activity of an enzyme involved in its synthesis (which was in turn regulated by Menin). The hypothalamus is a small but essential part of the brain located at the base, above the brainstem, responsible for regulating a wide range of bodily functions. It acts as a bridge between the nervous and endocrine systems, helping to maintain homeostasis by receiving input from various regions of the brain and the body. The hypothalamus regulates body temperature, hunger, thirst, sleep, mood, and hormone production, and plays a role in the body’s response to stress and controlling the release of hormones from the pituitary gland. Overall, the hypothalamus is critical for maintaining the body’s balance and health. Reversing Aging Through Menin Restoration Could reversing age-related Menin loss reverse signs of physiological aging? To test that, the authors delivered the gene for Menin into the hypothalamus of elderly (20-month-old) mice. Thirty days later, they found improved skin thickness and bone mass, along with better learning, cognition, and balance, which correlated with an increase in D-serine within the hippocampus, a central brain region important for learning and memory. Remarkably, similar benefits on cognition, though not on the peripheral signs of aging, could be induced by three weeks of dietary supplementation with D-serine. There is much left to be learned about Menin’s role in aging, including the upstream processes that lead to its decline, and there is much to learn about the potential for exploiting this pathway, including how much phenotypic aging can be slowed, and for how long, and whether supplementation with D-serine may trigger other changes, yet to be discovered. Nonetheless, Leng said, “We speculate that the decline of Menin expression in the hypothalamus with age may be one of the driving factors of aging, and Menin may be the key protein connecting the genetic, inflammatory, and metabolic factors of aging. D-serine is a potentially promising therapeutic for cognitive decline.” Leng adds, “Ventromedial hypothalamus (VMH) Menin signaling diminished in aged mice, which contributes to systemic aging phenotypes and cognitive deficits. The effects of Menin on aging are mediated by neuroinflammatory changes and metabolic pathway signaling, accompanied by serine deficiency in VMH, while restoration of Menin in VMH reversed aging-related phenotypes.” Reference: “Hypothalamic Menin regulates systemic aging and cognitive decline” by Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Tifei Yuan and Jie Zhang, 16 March 2023, PLoS Biology. DOI: 10.1371/journal.pbio.3002033
A groundbreaking study by the Garvan Institute has identified over 50,000 i-motifs in the human genome, revealing their significant role in gene regulation and potential in cancer therapy development. An innovative study of DNA’s hidden structures may open up new approaches for the treatment and diagnosis of diseases, including cancer. Researchers at the Garvan Institute have unveiled the first comprehensive map of over 50,000 i-motifs in the human genome, structures distinct from the classic double helix that may play crucial roles in gene regulation and disease. These findings highlight the potential of i-motifs in developing new therapies, particularly in targeting genes associated with cancers. Unraveling the Mysteries of DNA i-Motifs DNA is well-known for its double helix shape. But the human genome also contains more than 50,000 unusual ‘knot’-like DNA structures called i-motifs, researchers at the Garvan Institute of Medical Research have discovered. Published today (August 29) in The EMBO Journal is the first comprehensive map of these unique DNA structures, shedding light on their potential roles in gene regulation involved in disease. In a landmark 2018 study, Garvan scientists were the first to directly visualize i-motifs inside living human cells using a new antibody tool they developed to recognize and attach to i-motifs. The current research builds on those findings by deploying this antibody to identify i-motif locations across the entire genome. The knot-like i-motif structure protruding from DNA’s double helix has been mapped in 50,000 locations in the human genome, concentrated in key functional areas including regions that control gene activity. Credit: Garvan Institute “In this study, we mapped more than 50,000 i-motif sites in the human genome that occur in all three of the cell types we examined,” says senior author Professor Daniel Christ, Head of the Antibody Therapeutics Lab and Director of the Centre for Targeted Therapy at Garvan. “That’s a remarkably high number for a DNA structure whose existence in cells was once considered controversial. Our findings confirm that i-motifs are not just laboratory curiosities but widespread – and likely to play key roles in genomic function.” Key Roles of i-Motifs in Gene Regulation I-motifs are DNA structures that differ from the iconic double helix shape. They form when stretches of cytosine letters on the same DNA strand pair with each other, creating a four-stranded, twisted structure protruding from the double helix. Animation of DNA’s knot-like i-motif structure the team mapped in 50,000 locations in the human genome, concentrated in key functional areas including regions that control gene activity. Credit: Cristian David Pena Martinez / Garvan Institute The researchers found that i-motifs are not randomly scattered but concentrated in key functional areas of the genome, including regions that control gene activity. “We discovered that i-motifs are associated with genes that are highly active during specific times in the cell cycle. This suggests they play a dynamic role in regulating gene activity,” says Cristian David Peña Martinez, a research officer in the Antibody Therapeutics Lab and first author of the study. “We also found that i-motifs form in the promoter region of oncogenes, for instance, the MYC oncogene, which encodes one of cancer’s most notorious ‘undruggable’ targets. This presents an exciting opportunity to target disease-linked genes through the i-motif structure,” he says. Cristian David Pena Martinez, Associate Professor Sarah Kummerfeld and Professor Daniel Christ from the Garvan Institute of Medical Research. Credit: Garvan Institute Therapeutic Potential of i-Motifs “The widespread presence of i-motifs near these ‘holy grail’ sequences involved in hard-to-treat cancers opens up new possibilities for new diagnostic and therapeutic approaches. It might be possible to design drugs that target i-motifs to influence gene expression, which could expand current treatment options,” says Associate Professor Sarah Kummerfeld, Chief Scientific Officer at Garvan and co-author of the study. Professor Christ adds that mapping i-motifs was only possible thanks to Garvan’s world-leading expertise in antibody development and genomics. “This study is an example of how fundamental research and technological innovation can come together to make paradigm-shifting discoveries,” he says. Reference: “Human genomic DNA is widely interspersed with i-motif structures” by Cristian David Peña Martinez, Mahdi Zeraati, Romain Rouet, Ohan Mazigi, Jake Y Henry, Brian Gloss, Jessica A Kretzmann, Cameron W Evans, Emanuela Ruggiero, Irene Zanin, MarušičMaja, Janez Plavec, Sara N Richter, Tracy M Bryan, Nicole M Smith, Marcel E Dinger, Sarah Kummerfeld and Daniel Christ, 29 August 2024, The EMBO Journal. DOI: 10.1038/s44318-024-00210-5 Professor Daniel Christ is a Conjoint Professor at St Vincent’s Clinical School, Faculty of Medicine and Health, UNSW Sydney. Associate Professor Sarah Kummerfeld is a Conjoint Associate Professor at St Vincent’s Clinical School, Faculty of Medicine and Health, UNSW Sydney. This research was supported by funding from the National Health and Medical Research Council.
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