Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Vietnam OEM factory for footwear and bedding
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam graphene product OEM service
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China pillow ODM development service
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan OEM factory for footwear and bedding solutions
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Memory foam pillow OEM factory Thailand
An apoptotic, or dying cell, characterized by its wavy membrane, lies within a cultured sheet of epithelial cells. Credit: Yuma Cho and Junichi Ikenouchi, Kyushu University Researchers at Kyushu University have discovered a vital role for calcium in getting rid of dead cells in our body’s protective tissues. This finding is crucial for understanding how our bodies keep the outer and inner surfaces clean and safe from infection. The study, using advanced techniques, shows that when cells in these protective layers die, calcium helps the neighboring cells quickly remove them, maintaining a healthy barrier. Discovery of a New Cellular Mechanism Researchers at Kyushu University in Japan have uncovered a calcium-driven process crucial for removing dead cells, enhancing our understanding of how our bodies maintain health and prevent disease. Published recently in the journal Current Biology, their findings show that calcium ion levels are vital for effectively clearing dying cells, known as apoptotic cells, from epithelial tissues—these are the cells that form protective linings on body surfaces. The study utilized genetically modified epithelial tissue cultures, along with molecular markers and sophisticated imaging techniques to observe this process. Vital Barriers and Cellular Defense Epithelial cells cover the outer and inner surfaces of our bodies, including the skin and internal organs, serving as essential protective barriers. When these cells become damaged and die, a process known as apoptosis, adjacent cells quickly collaborate to eject the dead cells and close any openings. This action helps prevent the entry of harmful substances that could lead to infections or inflammation. While this process is critical for maintaining the integrity of epithelial barriers, the detailed mechanisms involved were not fully understood until this recent discovery. The study, led by Professor Junichi Ikenouchi and his colleagues, Dr. Kenji Matsuzawa and Mr. Yuma Cho, the first author, from Kyushu University, also included contributions from collaborators from the University of Tokyo and Health Sciences University of Hokkaido in Japan. In this image, the cell marked with an asterisk was damaged using a focused laser, triggering apoptosis. After an initial increase in general calcium levels around the dying cell (calcium wave), a sustained increase in calcium levels was observed at the interface between the apoptotic cell and the surrounding cells (marked B and D). This new mechanism is essential for expelling the apoptotic cell and preserving the integrity of the epithelium. Credit: Junichi Ikenouchi, originally published in https://doi.org/10.1016/j.cub.2024.08.057 Introduction to CaRE: A Calcium Response Mechanism To begin with, the team induced apoptosis in individual epithelial cells using a focused laser and observed the response in the surrounding cells. They then observed how nearby cells reacted by modifying them to express special calcium ion probes called GCaMP6, which allowed them to visualize real-time calcium changes. Interestingly, they found that the neighbors of the apoptotic cell showed a significant spike in calcium levels, particularly near the membrane regions interfacing with the dying cell. The researchers named this intriguing phenomenon the “calcium response in effectors of apical extrusion (CaRE).” Role of IP3 Receptors and Desmosomes in Cell Removal Delving deeper into this newly discovered mechanism, the team next examined the role of IP3 receptors, proteins present inside cells that help regulate calcium ion levels. They found that inhibiting the activity of IP3 receptors or removing their associated genes completely prevented the expulsion of apoptotic cells. Further analysis using advanced electron microscopy revealed that a specific subset of IP3 receptors, particularly those located near desmosomes, plays a key role in CaRE. Desmosomes are cell adhesion structures that form strong connections between cells, acting like buttons that hold them together. They are especially important in tissues like skin and organ linings, helping to keep everything intact and functioning properly. By ensuring neighboring cells adhere tightly, desmosomes play a key role in maintaining the structure and stability of our body’s tissues. The team found that the activation of IP3 receptors near desmosomes is necessary for triggering the contraction of a group of proteins known as actomyosin complex, which helps cells change shape and move, facilitating the removal of apoptotic cells. “Our study sheds light on a newfound role of IP3 receptors in desmosomes, the latter of which were previously thought to be involved only in mechanical connections between epithelial cells,” highlights Ikenouchi. As this study was conducted on cultured cells, the team notes that further analysis of the CaRE mechanism is needed to determine whether the mechanism also functions in living organisms, if it varies between different organ tissues, and whether other factors also play a role. Overall, this study advances our understanding of how our bodies maintain a healthy epithelium—something many of us take for granted. “Our findings provide valuable insights into understanding diseases caused by epithelial barrier disruption, such as atopic dermatitis and inflammatory bowel disease, and may contribute to the development of new preventive measures and treatments for chronic inflammation,” concludes Ikenouchi. Reference: “A sustained calcium response mediated by IP3 receptor anchoring to the desmosome is essential for apoptotic cell elimination” by Yuma Cho, Ikuko Koyama-Honda, Akihiko Tanimura, Kenji Matsuzawa and Junichi Ikenouchi, 23 September 2024, Current Biology. DOI: 10.1016/j.cub.2024.08.057
Mesopelagic fishes are an important element of marine food webs, a huge, still mostly untapped food resource, and great contributors to the biological carbon pump, whose future under climate change scenarios is unknown. According to a new study conducted by the ICM-CSIC, ocean warming will likely lead to smaller fish in the deep sea. This conclusion was reached through the analysis of fish otoliths found in geological formations dating back 700-800 thousand years. A study led by the University of Vienna, with participation from the Institut de Ciències del Mar (ICM-CSIC), has found that fish living in the dark depths of the ocean (below 200 meters in the water column) will likely shrink in size due to climate warming, which could have significant ecological consequences. The findings of this research have been published in the journal Proceedings of the Royal Society B: Biological Sciences. For its preparation, the authors obtained fish otoliths, which are small stones in the inner ear of bony fish used for sound and balance perception, from 800-700 thousand-year-old sedimentary formations on the island of Rhodes in the Aegean Sea. They then analyzed the otoliths to monitor changes in fish body size throughout glacial and interglacial periods. The morphology of these structures is particular to each fish species and their size directly reflects the size of the fish individual they come from, which allows researchers to identify them in order to reconstruct past fish faunas. “Thanks to the otolith analysis we have found that fishes during the interglacial period were smaller in size by 35%, when the global temperature had increased by 4 °C, which could happen again nowadays due to the ocean warming”, explains the leading author of the study, Konstantina Agiadi, from the University of Vienna. Small Fishes, Big Impacts The study, that is one of the few works that have so far addressed the consequences of climate warming on the deeper part of the oceans, the mesopelagic zone (200–1000 m depth), focused on the changes in “lanternfishes”, a group of small mesopelagic fishes that are named for their capacity to produce their own light. “Knowing the response of these organisms to ocean warming is key, since they contribute to ecosystem stability, reduce atmospheric carbon dioxide, and are a huge food resource for other organisms in the marine food web”, explains the ICM-CSIC researcher and co-author of the study Marta Coll, who adds that “these fish make up more than half the fish biomass in the deep sea, and about 100 times more than the total global annual fishery catches”. Lately, lanternfishes are important contributors to the biological carbon pump, a natural mechanism for reducing atmospheric carbon dioxide (CO2). Initially, phytoplanktonic organisms absorb CO2 from the atmosphere through photosynthesis. Then, every night, lanternfishes travel hundreds of meters upward to the surface of the oceans and return to the mesopelagic zone, thus bringing huge amounts of carbon from the surface to the deep ocean. Reference: “Palaeontological evidence for community-level decrease in mesopelagic fish size during Pleistocene climate warming in the eastern Mediterranean” by Konstantina Agiadi, Frédéric Quillévéré, Rafał Nawrot, Theo Sommeville, Marta Coll, Efterpi Koskeridou, Jan Fietzke and Martin Zuschin, 11 January 2023, Proceedings of the Royal Society B: Biological Sciences. DOI: 10.1098/rspb.2022.1994
Researchers have found a connection between a blood vessel cell’s ‘biography’ and its role in an adult organism. Researchers Discover That Blood Vessels Can Be Tailored to Specific Purposes Our family history tends to influence our future in a variety of ways. The same is true for blood vessels, according to a Weizmann Institute of Science study that was recently published in Nature. The scientists found that blood vessels develop from unexpected progenitors and went on to demonstrate that the blood vessels’ unusual origin impacts their role in the future. “We found that blood vessels must derive from the right source in order to function properly – it’s as if they remember where they came from,” says team leader Professor Karina Yaniv. The blood vessels that serve various organs vary greatly from one another. For instance, the kidneys filter the blood, therefore the walls of their blood vessels contain tiny holes that allow the efficient passage of substances. In the brain, the same walls are practically hermetic, guaranteeing a protective blockage known as the blood-brain barrier. Similarly, the lungs’ blood channel walls are also well adapted for another function, aiding gaseous exchange. Bone-forming (red) and lymphatic vessel (green) cells in a growing zebrafish fin. Credit: Weizmann Institute of Science Despite the vascular system’s critical importance, it is still unclear what causes the differences between the numerous blood vessels. These vessels had previously been thought to develop from either pre-existing blood vessels or progenitor cells that eventually mature and specialize to produce the vessel walls. However, recent research conducted by postdoctoral scholar Dr. Rudra N. Das from Yaniv’s laboratory in the Immunology and Regenerative Biology Department found that lymphatic vessels, a previously unidentified source, can also lead to the formation of blood vessels. This third source was discovered in transgenic zebrafish whose cells were marked with newly developed fluorescent markers that allow for tracing. Lymphatic Vessels in Blood Vessel Development “It was known that blood vessels can give rise to lymphatic vessels, but we’ve shown for the first time that the reverse process can also take place in the course of normal development and growth,” Das says. By tracing the growth of fins on the body of a juvenile zebrafish, Das saw that even before the bones had formed, the first structures to emerge in a fin were lymphatic vessels. Some of these vessels then lost their characteristic features, transforming themselves into blood vessels. Lymphatic vessel cells in a fin of a juvenile zebrafish (blue, top) give rise to the entire blood vessel network of this fin in the adult (blue, bottom). Credit: Weizmann Institute of Science This seemed inexplicably wasteful: Why hadn’t the blood vessels in the fins simply sprouted from a large nearby blood vessel? Das and colleagues provided an explanation by analyzing mutant zebrafish that lacked lymphatic vessels. They found that when lymphatic vessels were absent, the blood vessels did sprout in the growing fins of these mutants by branching from existing, nearby blood vessels. Surprisingly, however, in this case, the fins grew abnormally, with malformed bones and internal bleeding. A comparison revealed that in the mutant fish, excessive numbers of red blood cells entered the newly formed blood vessels in the fins, whereas in regular fish with lymphatic-derived blood vessels, this entry was controlled and restricted. The scarcity of red blood cells apparently created low-oxygen conditions known to benefit well-ordered bone development. In the mutant fish, on the other hand, an excess of red blood cells disrupted these conditions, which could well explain the observed abnormalities. In other words, only those blood vessels that had matured from lymphatic vessels were perfectly suited to their specialized function – in this case, proper fin development. Excessive numbers of red blood cells entered the newly formed blood vessels in the fins of mutant fish (right), whereas in regular fish (left), with lymphatic-derived blood vessels, this entry was controlled and restricted Credit: Weizmann Institute of Science Regeneration and Lymphatic Involvement Since zebrafish, unlike mammals, exhibit a remarkable capacity for regenerating most of their organs, Das and colleagues set out to explore how a fin would regrow following injury. They saw that the entire process they had observed during the fins’ development repeated itself during its regeneration – namely, lymphatic vessels grew first, and only later did they transform into blood vessels. “This finding supports the idea that creating blood vessels from different cell types is no accident – it serves the body’s needs,” Das says. (Left to right): Stav Safriel, Dr. Rudra N. Das, Prof. Karina Yaniv and Yaara Tevet. Credit: Weizmann Institute of Science The study’s findings are likely to be relevant to vertebrates other than zebrafish, humans included. “In past studies, whatever we discovered in fish was usually shown to be true for mammals as well,” Yaniv says. She adds: “On a more general level, we’ve demonstrated a link between the ‘biography’ of a blood vessel cell and its function in the adult organism. We’ve shown that a cell’s identity is shaped not only by its place of ‘residence,’ or the kinds of signals it receives from surrounding tissue but also by the identity of its ‘parents.’” The study could lead to new research paths in medicine and human development studies. It might, for example, help clarify the function of specialized vasculature in the human placenta that enables the establishment of a low-oxygen environment for embryo development. It could also contribute to the fight against common diseases: Heart attacks might be easier to prevent and treat if we identify the special features of the heart’s coronary vessels; new therapies may be developed to starve cancer of its blood supply if we know how exactly this supply comes about. Additionally, knowing how the brain’s blood vessels become impermeable may help deliver drugs to brain tissues more effectively. In yet another crucial direction, the findings may have application in tissue engineering, helping supply each tissue with the kind of vessel it needs. Yaniv, whose lab specializes in studying the lymphatic system, feels particularly vindicated by the new role the study has revealed for lymphatic vessels: “They are usually seen as poor cousins of blood vessels, but perhaps it’s just the opposite. They might actually take precedence in many cases.” The study was funded by the M. Judith Ruth Institute for Preclinical Brain Research. Reference: “Generation of specialized blood vessels via lymphatic transdifferentiation” by Rudra N. Das, Yaara Tevet, Stav Safriel, Yanchao Han, Noga Moshe, Giuseppina Lambiase, Ivan Bassi, Julian Nicenboim, Matthias Brückner, Dana Hirsch, Raya Eilam-Altstadter, Wiebke Herzog, Roi Avraham, Kenneth D. Poss and Karina Yaniv, 25 May 2022, Nature. DOI: 10.1038/s41586-022-04766-2
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